The REPAIR-AMI and ASTAMI trials: cell isolation procedures: reply
نویسندگان
چکیده
Haase J, Neuzner J, Germing A, Mark B, Assmus B, Tonn T, Dimmeler S, Zeiher AM: for the REPAIR-AMI trial. Improved clinical outcome after intracoronary administration of bonemarrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial. Eur Heart J 2006;27:2775–2783. 3. Lunde K, Solheim S, Aakhus S, Arnesen H, Abdelnoor M, Egeland T, Endresen K, Ilebekk A, Mangschau A, Fjeld JG, Smith HJ, Taraldsrud E, Grøgaard HK, Bjørnerheim R, Brekke M, Müller C, Hopp E, Ragnarsson A, Brinchmann JE, Forfang K. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med 2006;355:1199–1209. 4. http://www5.gelifesciences.com/aptrix/upp 01077.nsf/Content/Products?OpenDocument &parentid=17144002&moduleid=167164. 5. http://www.axis-shield.com/densityhome/ density/Data%20Sheet%20Lymphoprep.pdf.
منابع مشابه
Preclinical research Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction
Aims The recently published REPAIR-AMI and ASTAMI trial showed differences in contractile recovery of left ventricular function after infusion of bone marrow-derived cells in acute myocardial infarction. Since the trials used different protocols for cell isolation and storage (REPAIR-AMI: Ficoll, storage in X-vivo 10 medium plus serum; ASTAMI: Lymphoprep, storage in NaCl plus plasma), we compar...
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متن کاملThe REPAIR-AMI and ASTAMI trials: cell isolation procedures.
10 The time between myocar-dial infarction and intracoronary infusion therapy was nearly identical in the BMC and placebo group (median of 4 days), thus any spontaneous improvement in left ventri-cular ejection fraction (LVEF) prior to intra-coronary infusion therapy may have occurred to the same extent in both groups. As suggested by Marenzi and Bartor-elli, we re-analysed a potential effect o...
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